|
KMID : 1234420120400030278
|
|
Korean Journal of Microbiololgy and Biotechnology
2012 Volume.40 No. 3 p.278 ~ p.281
|
|
|
Effect of Inhibited Rab11-FIP3 Expression on Membrane Trafficking of TRPV1 in Dorsal Root Ganglion of Rat
|
|
Kim Mi-Ran
Lee Soon-Youl
|
|
|
Abstract
|
|
|
|
Not much is known about the membrane trafficking of TRPV1, a key player in pain transduction. Rab11-FIP3, which plays a role in various intracellular transportation pathways, has been reported to interact with TRPV1. In this study, in order to examine the role of Rab11-FIP3 in the membrane trafficking of TRPV1, Rab11-FIP3 expression in dorsal root ganglion (DRG) was inhibited using a siRNA technique. Transportation of TRPV1 to membranes was found to decrease when Rab11- FIP3 expression was inhibited, consistent with the results obtained with TRPV1-transfected HEK cells. Taken together, these results indicate that Rab11-FIP3 plays a role in the membrane trafficking of TRPV1.
|
|
|
KEYWORD
|
|
|
TRPV1, Rab11-FIP3, small interfering RNA (siRNA), membrane trafficking, dorsal root ganglion (DRG)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|